Endocrine Abstracts

BACKGROUND: Acromegaly is associated with abnormal bone metabolism, characterized by increased bone turnover. In health, PTH is secreted in a circadian rhythm, which is important in bone function. However, the effect of acromegaly on PTH secretion is unclear, with previous studies reporting increased, decreased or no change in PTH concentration. Furthermore, the presence of PTH circadian rhythmicity has not been defined in acromegaly.OBJECTIVES: To determine the effect of ...

BACKGROUND: AGHD is associated with increased prevalence of osteoporosis. Alterations in both parathyroid gland sensitivity to changes in calcium concentration and end-organ response to the effects of PTH play a role in the development of osteoporosis.OBJECTIVES: To investigate the effects of PTH (1-34) infusion on end-organ and parathyroid gland responsiveness.METHODS: 6 patients with severe AGHD were recruited. All patients were admitted, prior to commencement of GH ...

BACKGROUND: AGHD is associated with reduced BMD. GHR results in improvement in BMD, however, some patients remain osteopaenic despite all appropriate pituitary hormone replacement. PTH plays an important role in bone metabolism, with anabolic effects following intermittent administration. To date the difference in PTH activity and phosphocalcium metabolism between fully replaced AGHD patients with normal and reduced BMD has not been investigated.OBJECTIVES: To determine th...

BACKGROUND: AGHD is associated with osteoporosis. Alterations in parathyroid gland responsiveness to changes in calcium concentration play a role in the genesis of osteoporosis.OBJECTIVES: To investigate PTH response to hypo- and hypercalcaemic stimuli in AGHD.METHODS: 12 patients with untreated AGHD were consented to the study. Venous cannulae were inserted in each arm and half-hourly blood samples collected between 0900-1800hours for PTH, calcium and albumin. After 5...

A 77 year old man developed a severe progressive polyneuropathy associated with significant disability. He was also found to have type 2 diabetes mellitus and antibody-negative primary hypothyroidism and was treated with gliclazide and thyroxine to good effect. Nerve conduction studies showed a demyelinating type neuropathy that was not typical of diabetic neuropathy. Two years later he was admitted with an episode of severe hypoglycaemia accompanied by low blood pressure, hyp...

BACKGROUND: Untreated Adult Growth Hormone Deficiency (AGHD) is associated with reduced bone mineral density (BMD). PTH plays an important role in bone metabolism and reports suggest that bone and renal target cell insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the difference in PTH and phosphocalcium metabolism in untreated AGHD patients who have normal and reduced BMD.METHODS: 13 ...

BACKGROUND: Adult growth hormone deficiency (AGHD) is associated with osteoporosis. Growth Hormone replacement (GHR) results in increased bone mineral density (BMD), with greater benefit derived in men. PTH plays an important role in bone metabolism and reports suggest that bone and renal insensitivity to PTH may contribute to changes in bone turnover in AGHD.OBJECTIVES: To determine the gender difference in PTH, phosphocalcium metabolism and bone turnov...

Nuclear receptors regulate biological responses by acting as ligand dependent transcription factors in target cells. Their ability to modulate transcription is mediated by cofactors which are recruited to target genes by binding to receptors. They can either act as coactivators or corepressors and their roles include their ability to remodel chromatin and to recruit the basic transcription machinery. NRIP1 is transcriptional repressor which is recruited to nuclear receptors in...

BACKGROUND: Healthy and Adult Growth Hormone Deficient (AGHD) women exhibit elevated leptin concentrations compared with men. AGHD is characterised by obesity and associated with increased leptin concentration and decreased leptin pulsatility, however the gender variation in rhythm and pulse parameters is yet to be defined. Following growth hormone replacement (GHR), leptin concentration decreases and pulsatility increases preceding a reduction in body fat mass (BFM).<p cl...

Introduction: The aetiology of NENs vary; some are sporadic, others familial. An association between index NENs of the mid gut (ileum and colon) with subsequent colorectal primaries has been reported.Aim: We determined to evaluate the relationship between the diagnosis of an index primary malignancy and subsequent diagnosis of NEN.Methods: A population-based retrospective cohort study was under taken for persons with NEN diagnosis ...